Speaking on an IndieGames.com podcast, Edmund McMillen said:
We’re never going to make a game that couldn’t also be on PC. That’s a stupid thing for most indies to do. PC is crucial.
An excellent thing to hear for PC gaming fans, and it makes a lot of sense. Getting your game out on PC is so much easier then trying to get it approved by big console companies, and the huge PC following of indie titles makes it more likely to be a success as well.